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1

An update on the up and coming therapies to treat Osteoarthritis, a multifaceted disease

Roman-Blas, Jorge A., Bizzi, Emanuele, Largo, Raquel, Migliore, Alberto, Herrero-Beaumont, Gabriel

Journal:

Expert Opinion on Pharmacotherapy

Year:

2016

Language:

english

File:

PDF, 520 KB

english, 2016

2

Clinical settings in knee osteoarthritis: Pathophysiology guides treatment

Herrero-Beaumont, Gabriel, Roman-Blas, Jorge A., Bruyère, Olivier, Cooper, Cyrus, Kanis, John, Maggi, Stefania, Rizzoli, René, Reginster, Jean-Yves

Journal:

Year:

2016

Language:

english

File:

PDF, 463 KB

english, 2016

3

Efficacy and safety of a selective estrogen receptor β agonist, ERB-041, in patients with rheumatoid arthritis: A 12-week, randomized, placebo-controlled, phase II study

Jorge A. Roman-Blas, Santos Castañeda, Maurizio Cutolo, Gabriel Herrero-Beaumont

Journal:

Arthritis Care & Research

Year:

2010

Language:

english

File:

PDF, 100 KB

english, 2010

4

Progression of chondrogenesis in C3H10T1/2 cells is associated with prolonged and tight regulation of ERK1/2

M. Reza Seghatoleslami, Jorge A. Roman-Blas, Anne M. Rainville, Rozbeh Modaressi, Keith G. Danielson, Rocky S. Tuan

Journal:

Journal of Cellular Biochemistry

Year:

2003

Language:

english

File:

PDF, 371 KB

english, 2003

5

N-cadherin mediated distribution of β-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression

Rozbeh Modarresi, Toulouse Lafond, Jorge A. Roman-Blas, Keith G. Danielson, Rocky S. Tuan, M. Reza Seghatoleslami

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

6

MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures

J. Roman-Blas, A.S. Dion, M.R. Seghatoleslami, K. Giunta, P. Oca, S.A. Jimenez, C.J. Williams

Journal:

Journal of Cellular Physiology

Year:

2010

Language:

english

File:

PDF, 447 KB

english, 2010

7

Subchondral bone as a key target for osteoarthritis treatment

Santos Castañeda, Jorge A. Roman-Blas, Raquel Largo, Gabriel Herrero-Beaumont

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 299 KB

english, 2012

8

Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1β-stimulated human osteoarthritic synoviocytes and chondrocytes

Jorge A. Roman-Blas, María A. Contreras-Blasco, Raquel Largo, María A. Álvarez-Soria, Santos Castañeda, Gabriel Herrero-Beaumont

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 631 KB

english, 2009

9

NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

J.A. Roman-Blas, S.A. Jimenez

Journal:

Osteoarthritis and Cartilage

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

10

Modulation of TGF-β signaling by proinflammatory cytokines in articular chondrocytes

J.A. Roman-Blas, D.G. Stokes, S.A. Jimenez

Journal:

Osteoarthritis and Cartilage

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007

11

Correlation between arthroscopic and histopathological grading systems of articular cartilage lesions in knee osteoarthritis

C. Acebes, J.A. Roman-Blas, E. Delgado-Baeza, I. Palacios, G. Herrero-Beaumont

Journal:

Osteoarthritis and Cartilage

Year:

2009

Language:

english

File:

PDF, 600 KB

english, 2009

12

Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis

R. Largo, J.A. Roman-Blas, J. Moreno-Rubio, O. Sánchez-Pernaute, M.J. Martínez-Calatrava, S. Castañeda, G. Herrero-Beaumont

Journal:

Osteoarthritis and Cartilage

Year:

2010

Language:

english

File:

PDF, 1016 KB

english, 2010

13

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis

M. Bellido, L. Lugo, J.A. Roman-Blas, S. Castañeda, E. Calvo, R. Largo, G. Herrero-Beaumont

Journal:

Osteoarthritis and Cartilage

Year:

2011

Language:

english

File:

PDF, 680 KB

english, 2011

14

Rankl produced by articular chondrocytes induces bone loss associated with arthropathies

I. Prieto-Potin, M.J. Martínez-Calatrava, J.A. Román-Blas, R. Largo, L. Tardío, G. Herrero-Beaumont

Journal:

Osteoarthritis and Cartilage

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

15

Primary Osteoarthritis No Longer Primary: Three Subsets with Distinct Etiological, Clinical, and Therapeutic Characteristics

Gabriel Herrero-Beaumont, Jorge A. Roman-Blas, Santos Castañeda, Sergio A. Jimenez

Journal:

Seminars in Arthritis and Rheumatism

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

16

A7 COMP MUTATIONS AFFECT EXPRESSION PATTERNS OF EXTRACELLULAR MATRIX PROTEINS DURING IN VITRO CHONDROGENESIS

J.A. Roman-Blas, R.M. Seghatoleslami, A.S. Dion, K. van de Loo, P. Oca, F. Han, S.A. Jimenez, C.J. Williams

Journal:

Osteoarthritis and Cartilage

Year:

2006

Language:

english

File:

PDF, 38 KB

english, 2006

17

P358 THE ROLE OF OCCUPATIONAL MECHANICAL LOAD ON PAIN AND FUNCTIONAL LIMITATION IN PERUVIAN PATIENTS WITH SYMPTOMATIC KNEE OA

M. Pacheco, L.A. Mendoza, O. Vega, A. Salinas, H. Rueda Jr., M. Rivadeneyra, J.A. Roman-Blas

Journal:

Osteoarthritis and Cartilage

Year:

2006

Language:

english

File:

PDF, 41 KB

english, 2006

18

P355 THE INFLUENCE OF AGING ON THE PAIN/FUNCTIONAL LIMITATION RELATIONSHIP IN PERUVIAN PATIENTS WITH KNEE OA

L.A. Mendoza, A. Salinas, H. Rueda, M. Pacheco, E. Sedano, M. Rivadeneyra, J.A. Roman-Blas

Journal:

Osteoarthritis and Cartilage

Year:

2006

Language:

english

File:

PDF, 44 KB

english, 2006

19

089 PTH IMPROVES SYNOVITIS IN AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS PRECEDED BY OSTEOPOROSIS

L. Lugo, M. Bellido, O. Sánchez-Pernaute, J. Roman-Blas, S. Castañeda, R. Largo, G. Herrero-Beaumont

Journal:

Osteoarthritis and Cartilage

Year:

2010

Language:

english

File:

PDF, 59 KB

english, 2010

20

PTH [1-34] enhances bone response around titanium implants in a rabbit model of osteoporosis

M. Isabel Almagro, Jorge A. Roman-Blas, Miriam Bellido, Santos Castañeda, Raul Cortez, Gabriel Herrero-Beaumont

Journal:

Clinical Oral Implants Research

Year:

2012

Language:

english

File:

PDF, 493 KB

english, 2012

21

PR_002: Relationships of Patients’ Perception of Disease and Self-Reported Walking Tolerance to Pain and Functional Limitation in Peruvian Patients With Knee Osteoarthritis

Lenny A. Mendoza, Eduardo Sedano, Rosaura Quine, Maria Pacheco, Jorge A. Roman-Blas

Journal:

Archives of Physical Medicine and Rehabilitation

Year:

2006

Language:

english

File:

PDF, 55 KB

english, 2006

22

Does RANKL produced by articular chondrocytes actively participate in juxta-articular bone loss related to chronic arthritis?

I. Prieto-Potin⁎, M.J. Martínez-Calatrava, J.A. Román-Blas, L. Tardio, R. Largo, G. Herrero-Beaumont

Journal:

Year:

2012

Language:

english

File:

PDF, 78 KB

english, 2012

23

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis

L. Lugo, A. Villalvilla, R. Gómez, M. Bellido, O. Sánchez-Pernaute, R. Largo, G. Herrero-Beaumont, J.A. Roman-Blas

Journal:

Osteoarthritis and Cartilage

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

24

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

Miriam Bellido, Laura Lugo, Jorge A Roman-Blas…

Journal:

Arthritis Research & Therapy

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

25

Osteoarthritis associated with estrogen deficiency

Jorge A Roman-Blas, Santos Castañeda, Raquel Largo…

Journal:

Arthritis Research & Therapy

Year:

2009

Language:

english

File:

PDF, 1.87 MB

english, 2009

26

Is lecturing in Rheumatology Satellite Symposia a male attribute?

Santos Castañeda, Jorge A. Roman-Blas, Martine Cohen-Solal…

Journal:

Rheumatology International

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

27

An OA phenotype may obtain major benefit from bone-acting agents

Roman-Blas, Jorge A., Castañeda, Santos, Largo, Raquel, Lems, Willem F., Herrero-Beaumont, Gabriel

Journal:

Seminars in Arthritis and Rheumatism

Year:

2014

Language:

english

File:

PDF, 689 KB

english, 2014

28

Osteoarthritis: Osteoporotic OA: a reasonable target for bone-acting agents

Herrero-Beaumont, Gabriel, Roman-Blas, Jorge A.

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2013

Language:

english

File:

PDF, 332 KB

english, 2013

29

Selective estrogen receptor modulators (SERMs): New alternatives for osteoarthritis?

Lugo, L., Villalvilla, A., Largo, R., Herrero-Beaumont, G., Roman-Blas, J.A.

Journal:

Year:

2014

Language:

english

File:

PDF, 488 KB

english, 2014

30

SDF-1 signaling: a promising target in rheumatic diseases

Villalvilla, Amanda, Gomez, Rodolfo, Roman-Blas, Jorge A, Largo, Raquel, Herrero-Beaumont, Gabriel

Journal:

Expert Opinion on Therapeutic Targets

Year:

2014

Language:

english

File:

PDF, 565 KB

english, 2014

31

Subchondral bone remodelling and osteoarthritis

Jorge A Román-Blas,Santos Castañeda,Raquel Largo…

Journal:

Arthritis Research & Therapy

Year:

2012

Language:

english

File:

PDF, 174 KB

english, 2012

32

Targeting NF-κB: A Promising Molecular Therapy in Inflammatory Arthritis

Roman-Blas, Jorge A., Jimenez, Sergio A.

Journal:

International Reviews Of Immunology

Year:

2008

Language:

english

File:

PDF, 969 KB

english, 2008

33

PTH Increases Jaw Mineral Density in a Rabbit Model of Osteoporosis

Bellido, M., Lugo, L., Castaneda, S., Roman-Blas, J. A., Rufian-Henares, J. A., Navarro-Alarcon, M., Largo, R., Herrero-Beaumont, G.

Journal:

Journal of Dental Research

Year:

2010

Language:

english

File:

PDF, 330 KB

english, 2010

34

Osteoarthritis: a progressive disease with changing phenotypes

Castaneda, S., Roman-Blas, J. A., Largo, R., Herrero-Beaumont, G.

Journal:

Year:

2014

Language:

english

File:

PDF, 127 KB

english, 2014

35

Targeting subchondral bone in osteoporotic osteoarthritis

Roman-Blas, Jorge A, Herrero-Beaumont, Gabriel

Journal:

Arthritis Research & Therapy

Year:

2014

Language:

english

File:

PDF, 115 KB

english, 2014

36

Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis

Herrero-Beaumont, G., Roman-Blas, J. A., Largo, R., Berenbaum, F., Castaneda, S.

Journal:

Annals of the Rheumatic Diseases

Year:

2011

Language:

english

File:

PDF, 110 KB

english, 2011

37

DXA in the assessment of subchondral bone mineral density in knee osteoarthritis—A semi-standardized protocol after systematic review

Sepriano, Alexandre, Roman-Blas, Jorge A., Little, Robert D., Pimentel-Santos, Fernando, María Arribas, Jose, Largo, Raquel, Branco, Jaime C., Herrero-Beaumont, Gabriel

Journal:

Seminars in Arthritis and Rheumatism

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

38

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis

I. Prieto-potin, R. Largo, J. A. Roman-blas, G. Herrero-beaumont, D. A. Walsh

Year:

2015

Language:

english

File:

PDF, 2.05 MB

english, 2015

39

Chondroitin sulfate plus glucosamine sulfate does not show superiority over placebo in a randomised, double blind, placebo-controlled clinical trial in patients with knee osteoarthritis

Herrero-Beaumont, G., Román-Blas, J., Castañeda, S., Largo, R., Blanco, F.J.

Journal:

Osteoarthritis and Cartilage

Year:

2016

Language:

english

File:

PDF, 63 KB

english, 2016

40

Glucosamine sulfate for knee osteoarthritis: science and evidence-based use

Roman-Blas, Jorge A, Castañeda, Santos, Largo, Raquel, Herrero-Beaumont, Gabriel

Journal:

Year:

2010

Language:

english

File:

PDF, 469 KB

english, 2010

41

Cell Therapy Using Articular Chondrocytes Overexpressing BMP-7 or BMP-10 in a Rabbit Disc Organ Culture Model

Zhang, Yejia, Phillips, Frank M., Thonar, Eugene J.-M.A., Oegema, Theodore, An, Howard S., Roman-Blas, Jorge A., He, Tong-Chuan, Anderson, D Greg

Journal:

Year:

2008

Language:

english

File:

PDF, 1.04 MB

english, 2008

42

THE ROLE OF WORK-RELATED FACTORS ON PAIN AND FUNCTIONAL LIMITATION IN PATIENTS WITH SYMPTOMATIC KNEE OA

Cefferino, Cesar, Madariaga, H, Palomino, R, Pacheco, M, Vega, O, Salinas, A, Mendoza, L A., Rueda, H, Roman-Blas, J A.

Journal:

JCR Journal of Clinical Rheumatology

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

43

PAIN/FUNCTIONAL LIMITATION RELATIONSHIP IN PATIENTS WITH KNEE OA: THE INFLUENCE OF AGING

Mendoza, A Lenny, Salinas, A, Sedano, E, Rueda, H, Quine, R, Pacheco, M, Roman-Blas, J A.

Journal:

JCR Journal of Clinical Rheumatology

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

44

RELATIONSHIPS OF PATIENT??S PERCEPTION OF DISEASE, SELF-REPORTED WALKING TOLERANCE AND DURATION OF DISEASE TO PAIN AND FUNCTIONAL LIMITATION IN PATIENTS WITH KNEE OA

Eduardo, Sedano, Vega, O, Mendoza, L A., Quine, R, Pacheco, M, Salinas, A, Roman-Blas, J A.

Journal:

JCR Journal of Clinical Rheumatology

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

45

Chondroitin sulfate plus glucosamine sulfate shows no superiority over placebo in a randomized, double-blind, placebo-controlled clinical trial in patients with knee osteoarthritis

Roman-Blas, Jorge A., Castañeda, Santos, Sánchez-Pernaute, Olga, Largo, Raquel, Herrero-Beaumont, Gabriel

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 861 KB

english, 2016

46

The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits

Roman-Blas, Jorge A., Mediero, Aránzazu, Tardío, Lidia, Portal-Nuñez, Sergio, Gratal, Paula, Herrero-Beaumont, Gabriel, Largo, Raquel

Journal:

European Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 877 KB

english, 2017

47

Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration

Prieto-Potín, I, Roman-Blas, JA, Martínez-Calatrava, MJ, Gómez, R, Largo, R, Herrero-Beaumont, Gabriel

Journal:

Arthritis Research & Therapy

Year:

2013

Language:

english

File:

PDF, 2.86 MB

english, 2013

48

Reply to the letter of M Quintero

Roman-Blas, J.A., Sánchez-Pernaute, O., Largo, R., Herrero-Beaumont, G.

Journal:

Arthritis & Rheumatology

Year:

2017

Language:

english

File:

PDF, 539 KB

english, 2017

49

FRI0040 Transitional zones displacement of the subchondral bone layers in a model of osteoporosis and osteoarthritis in rabbits

Castañeda, S., Guede, D., Caeiro, J. R., Roman-Blas, J. A., Largo, R., Herrero-Beaumont, G.

Journal:

Annals of the Rheumatic Diseases

Year:

2013

Language:

english

File:

PDF, 253 KB

english, 2013

50

RANKL produced by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

Martínez-Calatrava, MJ, Prieto-Potín, I, Roman-Blas, J, Tardio, L, Largo, R, Herrero-Beaumont, G

Journal:

Annals of the Rheumatic Diseases

Year:

2012

Language:

english

File:

PDF, 67 KB

english, 2012